N-Formyl-Met-Leu-Phe (CAS 59880-97-6): R&D Systems
Catalog Number: 1921
Alternate Names: fMLP
Biological Activity
Endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.
Technical Data
  • M.Wt:
    437.55
  • Formula:
    C21H31N3O5S
  • Sequence:
    MLF

    (Modifications: Met-1 = N-formyl-Met)

  • Solubility:
    Soluble to 4.38 mg/ml in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    59880-97-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors.
    Kreutzer et al.
    Immunopharmacology, 1978;1:39
  2. Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu.
    Mills et al.
    J.Biol.Chem., 2000;275:39012
  3. Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe.
    Spilberg et al.
    Inflammation, 1984;8:73
Citations:

The citations listed below are publications that use Tocris products. Selected citations for N-Formyl-Met-Leu-Phe include:

1 Citations: Showing 1 - 1

  1. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.
    Authors: Tomilov Et al.
    J Biol Chem 2010;285:1153

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