Catalog Number: 0573
Chemical Name: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
Biological Activity
Potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).
Technical Data
  • M.Wt:
    198.09
  • Formula:
    C6H11N3.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    16503-22-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A third histamine receptor subtype - characterization, localization and functions of the H3-receptor.
    Schwartz et al.
    Agents Actions, 1990;30:13
  2. Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein.
    Zweig et al.
    J.Neurochem., 1992;59:1661
  3. Distribution, properties, and functional characteristics of three classes of histamine receptor.
    Hill et al.
    Pharmacol.Rev., 1990;42:45

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