Nα-Methylhistamine dihydrochloride
Chemical Name: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
Biological Activity
Nα-Methylhistamine dihydrochloride is a potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Distribution, properties, and functional characteristics of three classes of histamine receptor.
Hill et al.
Pharmacol.Rev., 1990;42:45 -
A third histamine receptor subtype - characterization, localization and functions of the H3-receptor.
Schwartz et al.
Agents Actions, 1990;30:13 -
Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein.
Zweig et al.
J.Neurochem., 1992;59:1661
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