Potent histamine agonist, particularly at H3
receptors (potency relative to histamine is 81, 185, and 270% at H1
respectively). Also displays agonist properties at H4
receptors to which it binds with moderate affinity (Ki
= 23 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A third histamine receptor subtype - characterization, localization and functions of the H3-receptor.
Schwartz et al.
Agents Actions, 1990;30:13
Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein.
Zweig et al.
Distribution, properties, and functional characteristics of three classes of histamine receptor.
Hill et al.