Catalog Number: 0500
Biological Activity
Powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthetic polyamine analogues as antineoplastics.
    Bergeron et al.
    J.Med.Chem., 1988;31:1183
  2. Synthesis and bioloigcal evaluation of aminopolyamines.
    Bergeron et al.
    J.Med.Chem., 2005;48:3099
  3. Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.
    Vertino et al.
    Mol.Pharmacol., 1991;39:487
  4. Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1,N12-bis(ethyl)spermine.
    Porter et al.
    Biochem.J., 1990;268:207
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