Catalog Number: 2213
Chemical Name: 2-[(3,3-Diphenylpropyl)amino]acetamide hydrochloride
Biological Activity
Selective, non-competitive NMDA receptor antagonist (IC50 = 5 μM); binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Displays neuroprotective activity in vivo. Brain-penetrant.
Technical Data
  • M.Wt:
    304.82
  • Formula:
    C17H20N2O.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1177583-87-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity.
    Planells-Cases et al.
    J.Pharmacol.Exp.Ther., 2002;302:163
Citations:

The citations listed below are publications that use Tocris products. Selected citations for N20C hydrochloride include:

1 Citations: Showing 1 - 1

  1. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.
    Authors: Roy Et al.
    J Biol Chem 2014;9:e101883

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