Selective, non-competitive NMDA receptor antagonist (IC50
= 5 μ
M); binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+
influx. Displays neuroprotective activity in vivo
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A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity.
Planells-Cases et al.
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