Chemical Name: N-Cyclohexyladenosine
Biological ActivityHigh affinity adenosine A1 receptor agonist (Kd values are 0.7 and 6 nM for bovine and guinea pig brain membranes, respectively). Reduces light-induced circadian phase delays. Exhibits protective effect in lysolecithin-induced demyelination model. When administered prior to ischemia, improves functional recovery of heart in a mouse model of ischemia-reperfusion injury. Induces hypothermia following icv administration in mice.
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Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.
Bruns et al.
Adenosine A1 receptors regulate the response of the mouse circadian clock to light.
Sigworth and Rea et al.
Brain Res., 2003;960:246
Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies.
Asghari et al.
Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts.
Shao et al.
PLoS One, 2017;12:e0177315
Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia.
Futatsuki et al.
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