N⁶-Cyclohexyladenosine

Key Product Details

Product Description

N⁶-Cyclohexyladenosine is a high affinity adenosine A₁ receptor agonist (K_d values are 0.7 and 6 nM for bovine and guinea pig brain membranes, respectively). Reduces light-induced circadian phase delays. Exhibits protective effect in lysolecithin-induced demyelination model. When administered prior to ischemia, improves functional recovery of heart in a mouse model of ischemia-reperfusion injury. Induces hypothermia following icv administration in mice.

Product Specifications for N⁶-Cyclohexyladenosine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for N⁶-Cyclohexyladenosine

The following data is based on the product molecular weight 349.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Futatsuki Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia. Sci.Rep. 2018 PMID: 29426934
• Shao Adenosine A₁ receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts. PLoS One 2017 PMID: 28493997
• Sigworth and Rea Adenosine A₁ receptors regulate the response of the mouse circadian clock to light. Brain Res. 2003 PMID: 12505678
• Asghari Adenosine A₁ receptor agonist, N⁶-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J.Neurol.Sci. 2013 PMID: 23260322
• Bruns Adenosine receptors in brain membranes: binding of N6-cyclohexyl[³H]adenosine and 1,3-diethyl-8-[³H]phenylxanthine. Proc.Natl.Acad.Sci.U.S.A. 1980 PMID: 6254090

Product Documents for N⁶-Cyclohexyladenosine