Chemical Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
Biological ActivityNafamostat mesylate is a broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC50 = 22.50 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Nafamostat mesilate is an extremely potent inhibitor of human tryptase.
Mori et al.
A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium.
Sendo et al.
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
Chen et al.
J.Allergy Clin.Immunol., 2006;118:105
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Wang et al.
Cell Research, 2020;30:269
Citation for Nafamostat mesylate
The citations listed below are publications that use Tocris products. Selected citations for Nafamostat mesylate include:
1 Citation: Showing 1 - 1
Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage.
Authors: Scott Et al.
Sci Rep 2018;8:3363
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Used in cell culture to view the effects compared to others. Need qPCR to see results.