Chemical Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
Biological ActivityBroad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Nafamostat mesilate is an extremely potent inhibitor of human tryptase.
Mori et al.
A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium.
Sendo et al.
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
Chen et al.
J.Allergy Clin.Immunol., 2006;118:105
Citation for Nafamostat mesylate
The citations listed below are publications that use Tocris products. Selected citations for Nafamostat mesylate include:
1 Citation: Showing 1 - 1
Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage.
Authors: Scott Et al.
Sci Rep 2018;8:3363
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Nafamostat mesylate
There are currently no reviews for this product. Be the first to review Nafamostat mesylate and earn rewards!
Have you used Nafamostat mesylate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image