Nafamostat mesylate

Tocris Bioscience | Catalog # 3081

Serine protease inhibitor; inhibits tryptase
Tocris Bioscience

Key Product Details

Description

Serine protease inhibitor; inhibits tryptase
View all TMPRSS2 Inhibitors »

Product Description

Nafamostat mesylate is a broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC50 = 22.50 μM).

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Product Specifications for Nafamostat mesylate

Molecular Weight

539.59

Formula

C19H17N5O2.2CH4O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate

CAS Number

82956-11-4

PubChem ID

54953

InChI Key

SRXKIZXIRHMPFW-UHFFFAOYSA-N

SMILES

CS(=O)(O)=O.NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 53.96 100
DMSO 53.96 100

Preparing Stock Solutions for Nafamostat mesylate

The following data is based on the product molecular weight 539.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for Nafamostat mesylate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Nafamostat mesylate

For research use only

Related Research Areas

Infectious Diseases

Citations for Nafamostat mesylate

Customer Reviews for Nafamostat mesylate (1)

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  • Used in cell culture
    Name: Anonymous
    Species: Human
    Cell Line/Tissue: ES cells
    Verified Customer | Posted 11/19/2020
    Used in cell culture to view the effects compared to others. Need qPCR to see results.

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