Naltrexone hydrochloride

Catalog # Availability Size / Price Qty
Naltrexone hydrochloride | CAS No. 16676-29-2 | Miscellaneous/Non-selective Opioid Antagonists
1 Image
Description: Non-selective opioid antagonist

Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydromorphinan-6-one hydrochloride

Purity: ≥99%

Product Details
Citations (9)

Biological Activity

Naltrexone hydrochloride is an opioid antagonist.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

  1. Naltrexone, opiate addiction, and endorphins.
    Gold et al.
    Med.Res.Rev., 1982;2:211
  2. Naltrexone-induced opiate receptor supersensitivity.
    Zukin et al.
    Brain Res., 1982;245:285
  3. Supersensitivity of brain opiate receptor subtypes after chronic naltr. treatment.
    Tempel et al.
    Life Sci., 1982;31:1401

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Citations for Naltrexone hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Naltrexone hydrochloride include:

9 Citations: Showing 1 - 9

  1. Latent Sensitization in a Mouse Model of Ocular Neuropathic Pain.
    Authors: Cho Et al.
    Transl Vis Sci Technol  2019;8:6
  2. Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice.
    Authors: Smith Et al.
    Proc Natl Acad Sci U S A  2016;113:13893
  3. Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization.
    Authors: Leskelä Et al.
    J Biol Chem  2012;287:5008
  4. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
    Authors: Jones Et al.
    Biochem Pharmacol  2010;80:1478
  5. Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice.
    Authors: Chung Et al.
    Hum Mol Genet  2010;11:847
  6. Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2010;107:13117
  7. Sustained mor. treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
    Authors: Tumati Et al.
    J Pain  2009;330:810
  8. Sustained mor. treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner.
    Authors: Yue Et al.
    Eur J Pharmacol  2008;584:272
  9. N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface.
    Authors: Markkanen and Petäjä-Repo
    J Biol Chem  2008;283:29086


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