Naltriben mesylate
Discontinued Product
Chemical Name: 17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate
Purity: ≥98%
Biological Activity
Naltriben mesylate is a selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg�ATP
S Ferioli, S Zierler, J Zai beta erer, J Schredelse, T Gudermann, V Chubanov
Sci Rep, 2017;7(1):8806. -
Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole.
Portoghese et al.
J.Med.Chem., 1991;34:1715 -
Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat.
Thorat and Hammond
J.Pharmacol.Exp.Ther., 1997;283:1185 -
Involvement of delta2 opioid receptors in the development of mor. dependence in mice.
Miyamoto et al.
J.Pharmacol.Exp.Ther., 1993;264:1141
Product Datasheets
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Citation for Naltriben mesylate
The citations listed below are publications that use Tocris products. Selected citations for Naltriben mesylate include:
1 Citation: Showing 1 - 1
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Heterodimerization of μ and δ opioid receptors: A role in opiate synergy.
Authors: Gomes Et al.
Exp Neurobiol 2000;20:RC110
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