Catalog Number: 0892
Chemical Name: 17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate
Biological Activity
Selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.
Technical Data
  • M.Wt:
    511.59
  • Formula:
    C26H25NO4.CH3SO3H
  • Solubility:
    Soluble to 50 mM in DMSO with gentle warming
  • Storage:
    Desiccate at RT
  • CAS No:
    122517-78-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Minnesota
Background References
  1. Involvement of delta2 opioid receptors in the development of morphine dependence in mice.
    Miyamoto et al.
    J.Pharmacol.Exp.Ther., 1993;264:1141
  2. Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat.
    Thorat and Hammond
    J.Pharmacol.Exp.Ther., 1997;283:1185
  3. Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole.
    Portoghese et al.
    J.Med.Chem., 1991;34:1715
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Naltriben mesylate include:

1 Citations: Showing 1 - 1

  1. Heterodimerization of μ and δ opioid receptors: A role in opiate synergy.
    Authors: Gomes Et al.
    Exp Neurobiol 2000;20:RC110

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