Catalog Number: 0553
Chemical Name: 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide
Biological Activity
5-HT1A antagonist.
Technical Data
  • M.Wt:
    474.4
  • Formula:
    C23H27N3O3.HBr
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    115338-32-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Arylpiperazine derivatives as high affinity 5-HT1A serotonin ligands.
    Glennon et al.
    J.Med.Chem., 1988;31:1968
  2. Effects of the putative 5-HT1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT1A receptor agonist 8-OH-DPAT in the rat.
    Douris
    Eur.J.Pharmacol., 1992;219:105
  3. NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
    Williams and Glennon
    Eur.J.Pharmacol., 1988;154:339
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NAN-190 hydrobromide include:

2 Citations: Showing 1 - 2
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  1. Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
    Authors: Demarque and
    Neuron 2010;67:321
  2. Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
    Authors: Pagano Et al.
    Physiol Behav 2008;20:1190

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