Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione
Biological ActivitySTAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Suppression of cancer relapse and metastasis by inhibiting cancer stemness.
Li et al.
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