1.7 channel blocker (IC50
= 370 nM). Exhibits >85-fold selectivity for Nav
1.7 over Nav
1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
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All Tocris products are intended for laboratory research use only.
3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.
Macsari et al.