NAV 26

Key Product Details

Product Description

NAV 26 is a selective Na_v1.7 channel blocker (IC₅₀ = 370 nM). Exhibits >85-fold selectivity for Na_v1.7 over Na_v1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.

Product Specifications for NAV 26

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NAV 26

The following data is based on the product molecular weight 434.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.51 mL	23.02 mL
5 mM	0.46 mL	2.30 mL	4.60 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Macsari 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 2012 PMID: 22770500

Product Documents for NAV 26