NAV 2729

Catalog # Availability Size / Price Qty
NAV 2729 | CAS No. 419547-11-8 | ARF GTPase Inhibitors
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Description: Selective ARF6 inhibitor

Chemical Name: 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Purity: ≥98%

Product Details
Citations (5)

Biological Activity

NAV 2729 is a selective ARF6 inhibitor (IC50 = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma.
    Yoo et al.
    Cancer Cell., 2016;29:889
  2. Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
    BT Finicle, KH Eckenstein, AS Revenko, BA Anderson, WB Wan, AN McCracken, D Gil, DA Fruman, S Hanessian, PP Seth, AL Edinger
    Nucleic Acids Research, 2023;0(0):.

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Citations for NAV 2729

The citations listed below are publications that use Tocris products. Selected citations for NAV 2729 include:

5 Citations: Showing 1 - 5


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