Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron
Biological ActivityNBC 19 is a potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Boron-based inhibitors of the NLRP3 inflammasome.
Baldwin et al.
Cell Chem.Biol., 2017;24:1321
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.
Redondo-Castro et al.
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