NBC 19

Key Product Details

Product Description

NBC 19 is a potent NLRP3 inflammasome inhibitor (IC₅₀ = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.

Licensing Information

Sold under license from the University of Manchester.

Product Specifications for NBC 19

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NBC 19

The following data is based on the product molecular weight 491.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.17 mL	20.34 mL
5 mM	0.41 mL	2.03 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Redondo-Castro Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 2018 PMID: 29618797
• Baldwin Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 2017 PMID: 28943355

Product Documents for NBC 19