NBI 27914 hydrochloride

  ( 12 citations )    
Product Datasheet
Catalog Number:1591
Chemical Name:5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
Selective, non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonist (Ki = 1.7 nM); has no activity at CRF2 receptors. Blocks behavioral seizures in vivo.
Technical Data
  • M.Wt:
    470.66
  • Formula:
    C18H20Cl4N4.HCl
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    1215766-76-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NBI 27914 hydrochloride include:

12 Citations: Showing 1 - 10
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  1. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
    Authors: Navarro Et al.
    Stroke  2015;35:6639
  2. Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities.
    Authors: Rajbhandari Et al.
    J Neurosci  2015;35:14270
  3. Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses.
    Authors: Ji Et al.
    Mol Pain  2013;9:2
  4. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
    Authors: Silberman and Winder
    Neuropharmacology  2013;70:316
  5. Role of nesfatin-1 in a rat model of visceral hypersensitivity.
    Authors: Jia Et al.
    Cereb Cortex  2013;19:3487
  6. Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice.
    Authors: Lowery-Gionta Et al.
    J Neurosci  2012;32:3405
  7. CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.
    Authors: Wang Et al.
    PLoS One  2011;6:e16377
  8. NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.
    Authors: Delawary Et al.
    Mol Brain  2010;3:37
  9. Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon.
    Authors: Liu Et al.
    Br J Pharmacol  2010;159:222
  10. Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
    Authors: Nakamura and Sapru
    Am J Physiol Heart Circ Physiol  2009;296:H2022
  11. Expression, binding, and signaling properties of CRF2(a) receptors endogenously expressed in human retinoblastoma Y79 cells: passage-dependent regulation of functional receptors.
    Authors: Gutknecht Et al.
    J Neurochem  2008;104:926
  12. Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex.
    Authors: Gallopin Et al.
    J Neurosci  2006;16:1440
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