NBI 27914 hydrochloride

Key Product Details

Product Description

NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor₁ (CRF₁) receptor antagonist (K_i = 1.7 nM); has no activity at CRF₂ receptors. Blocks behavioral seizures in vivo.

Product Specifications for NBI 27914 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NBI 27914 hydrochloride

The following data is based on the product molecular weight 470.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Chen Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor₁ receptor antagonists. J.Med.Chem. 1996 PMID: 8893829
• McCarthy Recent advances with the CRF₁ receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr.Pharm.Des. 1999 PMID: 10213797
• Baram The CRF₁ receptor mediates the excitatory actions of cortico. releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997 PMID: 9372207

Product Documents for NBI 27914 hydrochloride