NBI 27914 hydrochloride

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NBI 27914 hydrochloride | CAS No. 1215766-76-9 | CRF1 Receptor Antagonists
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Description: Selective non-peptide CRF1 antagonist

Chemical Name: 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride

Purity: ≥99%

Product Details
Citations (12)
Supplemental Products

Biological Activity

NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonist (Ki = 1.7 nM); has no activity at CRF2 receptors. Blocks behavioral seizures in vivo.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NBI 27914 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for NBI 27914 hydrochloride include:

12 Citations: Showing 1 - 10

  1. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
    Authors: Navarro Et al.
    Stroke  2015;35:6639
  2. Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala NE Systems that Promote PTSD-Like Startle Abnormalities.
    Authors: Rajbhandari Et al.
    J Neurosci  2015;35:14270
  3. Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses.
    Authors: Ji Et al.
    Mol Pain  2013;9:2
  4. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
    Authors: Silberman and Winder
    Neuropharmacology  2013;70:316
  5. Role of nesfatin-1 in a rat model of visceral hypersensitivity.
    Authors: Jia Et al.
    Cereb Cortex  2013;19:3487
  6. Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice.
    Authors: Lowery-Gionta Et al.
    J Neurosci  2012;32:3405
  7. CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.
    Authors: Wang Et al.
    PLoS One  2011;6:e16377
  8. NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.
    Authors: Delawary Et al.
    Mol Brain  2010;3:37
  9. Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon.
    Authors: Liu Et al.
    Br J Pharmacol  2010;159:222
  10. Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
    Authors: Nakamura and Sapru
    Am J Physiol Heart Circ Physiol  2009;296:H2022


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