Chemical Name:1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
Biological Activity High affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.
Soluble to 100 mM in DMSO
Store at -20°C
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