High affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki
values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo
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Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.
Chen et al.
In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.
Choi et al.