NBI 35965 hydrochloride

Key Product Details

Product Description

NBI 35965 hydrochloride is a potent and selective corticotropin-releasing factor receptor 1 (CRF₁) antagonist (K_i values are 4 and > 10000 nM at CRF₁ and CRF₂ respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC₅₀ values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.

Product Specifications for NBI 35965 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NBI 35965 hydrochloride

The following data is based on the product molecular weight 437.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.84 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

• Hoare Mechanism of corticotropin-releasing factor type I receptor regulation by non-peptide antagonists. Mol.Pharmacol. 2003 PMID: 12606786
• Gross Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. J.Med.Chem. 2005 PMID: 16134945
• Million A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 2003 PMID: 12957366

Product Documents for NBI 35965 hydrochloride