NDT 9513727

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NDT 9513727 | CAS No. 439571-48-9 | Complement Signaling inhibitors
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Description: Potent, selective human C5a receptor negative allosteric modulator (NAM)

Chemical Name: N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Potent C5a receptor (C5aR) negative allosteric modulator (NAM) (IC50 = 11.6 nM); selective for human C5aR (IC50 values for rat and mouse C5aR are > 10 μM). Exhibits inverse agonist pharmacokinetics. Blocks degranulation response in C5a-stimulated U937 cells (IC50 = 7.1 nM). Exhibits selectivity for primate and gerbil receptor over other species. Orally bioavailable.

Technical Data

M.Wt:
573.68
Formula:
C36H35N3O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
439571-48-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for NDT 9513727

The citations listed below are publications that use Tocris products. Selected citations for NDT 9513727 include:

1 Citation: Showing 1 - 1

  1. Orthosteric and allosteric action of the C5a receptor antagonists.
    Authors: Liu
    Nat Struct Mol Biol  2018;25:472

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