Catalog Number: 2324
Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Biological Activity
ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
Technical Data
  • M.Wt:
    259.33
  • Formula:
    C13H13N3OS
  • Solubility:
    Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    4311-88-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
    Degterev et al.
    Nat.Chem.Biol., 2005;1:112
  2. Identification of RIP1 kinase as a specific cellular target of necrostatins.
    Degterev et al.
    Nat.Chem.Biol., 2008;4:313
  3. Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.
    Linkermann et al.
    , 2012;81:751
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Necrostatin-1 include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
    Authors: Kim
    Journal of Translational Medicine 2017;15(1):123
  2. The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
    Authors: Sagher Et al.
    Cancer Cell Int 2014;14:75

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