Biological Activity ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming
Store at RT
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For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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