Necrostatin-1

Catalog # Availability Size / Price Qty
2324/50
2324/10
Necrostatin-1 | CAS No. 4311-88-0 | RIP Kinase Inhibitors
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Description: RIP1 kinase inhibitor; inhibits necroptosis

Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Purity: ≥99%

Product Details
Citations (4)
Reviews

Biological Activity

ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Technical Data

M.Wt:
259.33
Formula:
C13H13N3OS
Solubility:
Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
4311-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Necrostatin-1

The citations listed below are publications that use Tocris products. Selected citations for Necrostatin-1 include:

4 Citations: Showing 1 - 4

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