Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Biological ActivityATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Degterev et al.
Identification of RIP1 kinase as a specific cellular target of necroSTAT.
Degterev et al.
Citations for Necrostatin-1
The citations listed below are publications that use Tocris products. Selected citations for Necrostatin-1 include:
4 Citations: Showing 1 - 4
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Authors: Chefetz Et al.
Cell Rep 2019;26:3061
ONC201 kills breast cancer cells in vitro by targeting mitochondria.
Authors: Greer Et al.
Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
Journal of Translational Medicine 2017;15(1):123
The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
Authors: Sagher Et al.
Cancer Cell Int 2014;14:75
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