Necrostatin-1

  ( 2 citations )    
Product Datasheet
Catalog Number:2324
Chemical Name:5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Product Details
Citations (2)
Reviews
Biological Activity
ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
Technical Data
  • M.Wt:
    259.33
  • Formula:
    C13H13N3OS
  • Solubility:
    Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    4311-88-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Necrostatin-1 include:

2 Citations: Showing 1 - 2
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  1. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
    Authors: Kim
    Journal of Translational Medicine  2017;15(1):123
  2. The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
    Authors: Sagher Et al.
    Cancer Cell Int  2014;14:75

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