Catalog Number: 2777
Chemical Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
Biological Activity
Serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Displays no activity at 5-HT1B and 5-HT1D receptors. Active in models predictive of antidepressant potential.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in 1eq. HCl and to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nefazodone: preclinical pharmacology of a new antidepressant.
    Eison et al.
    Psychopharmacol.Bull., 1990;26:311
  2. Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression.
    Davis et al.
    Drugs, 1997;53:608
  3. LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine2A receptor antagonist: a comparison with the antidepressant, nefazodone.
    Pullar et al.
    Eur.J.Pharmacol., 2000;407:39
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