Catalog Number: 2851
Alternate Names: DM 9384
Chemical Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
Biological Activity
Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mechanisms of action of cognitive enhancers on neuroreceptors.
    Narahashi et al.
    Biol.Pharm.Bull., 2004;27:1701
  2. The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo.
    Ueda et al.
    J.Pharmacol.Exp.Ther., 2004;309:200
  3. Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats.
    Kitano et al.
    Epilepsia, 2005;46:1561
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