Nelfinavir mesylate

Catalog # Availability Size / Price Qty
3766/10
3766/50
Nelfinavir mesylate | CAS No. 159989-65-8 | Additional Synthetic Protease Inhibitors
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Description: Potent HIV-1 protease inhibitor
Alternative Names: AG 1341

Chemical Name: (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate

Purity: ≥98%

Product Details
Reviews

Biological Activity

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro.

Technical Data

M.Wt:
663.89
Formula:
C32H45N3O4S.CH4O3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
159989-65-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo.
    Gills et al.
    Clin.Cancer Res., 2007;13:5183
  2. Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease.
    Shetty et al.
    Antimicrob.Agents Chemother., 1996;40:110
  3. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.
    Patick et al.
    Antimicrob.Agents Chemother., 1996;40:29

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