Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki
= 2 nM) in vitro
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All Tocris products are intended for laboratory research use only.
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Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease.
Shetty et al.
Antimicrob.Agents Chemother., 1996;40:110
Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.
Patick et al.
Antimicrob.Agents Chemother., 1996;40:29
Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo.
Gills et al.
Clin.Cancer Res., 2007;13:5183