Chemical Name: cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
Biological ActivityHighly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective binding of YM-09151-2, a new potent neuroleptic, to D2-DArgic receptors.
Terai et al.
[3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes.
Ujike et al.
5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and cloz.
Assie et al.
Citation for Nemonapride
The citations listed below are publications that use Tocris products. Selected citations for Nemonapride include:
1 Citation: Showing 1 - 1
Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay
Authors: Gadgaard & Jensen
Biochem Pharmacol 2020;175
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