Catalog Number: 1746
Alternate Names: YM 09151, YM 09151-2
Chemical Name: cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
Biological Activity
Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in ethanol and to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine.
    Assie et al.
    Eur.J.Pharmacol., 1997;334:141
  2. [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes.
    Ujike et al.
    Neuroreport, 1996;7:1057
  3. Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors.
    Terai et al.
    Jpn.J.Pharmacol., 1983;33:749
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