Nexinhib20

Catalog # Availability Size / Price Qty
6089/25
6089/5
Other Small Monomeric GTPase Inhibitors Small Molecule
1 Image
Description: Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo

Chemical Name: 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one

Purity: ≥98%

Product Details
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Biological Activity

Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.

Technical Data

M.Wt:
300.31
Formula:
C15H16N4O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
331949-35-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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