NFAT inhibitor, Cell Permeable

Tocris Bioscience | Catalog # 5710

Cell permeable NFAT inhibitor
Tocris Bioscience

Key Product Details

Description

Cell permeable NFAT inhibitor

Alternative Names

11R-VIVIT
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Product Description

NFAT inhibitor, Cell Permeable is an NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Reduces inflammation and epithelial damage in a mouse model of colitis. In an animal model of Alzheimer's disease NFAT inhibitor improves cognitive and synaptic function, reduces glial activation and lowers amyloid levels; in vitro it reduces glutamate dysregulation and neuron hyperactivity.

Product Specifications for NFAT inhibitor, Cell Permeable

Molecular Weight

3573.15

Formula

C147H259N67O36S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

592517-80-1

PubChem ID

16140839

InChI Key

VNTCWMOQGXMIQP-PIQGMSCVSA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for NFAT inhibitor, Cell Permeable

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NFAT inhibitor, Cell Permeable

For research use only

Citations for NFAT inhibitor, Cell Permeable

Customer Reviews for NFAT inhibitor, Cell Permeable (1)

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  • To determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line
    Name: Meghan Bradshaw
    Species: Human
    Cell Line/Tissue: IC-21 cell line
    Verified Customer | Posted 02/20/2019
    NFAT function in macrophages and we worked to determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line.
    NFAT inhibitor, Cell Permeable 5710

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