NFAT inhibitor, Cell Permeable

Catalog # Availability Size / Price Qty
5710/1
Cat.No. 5710 - NFAT inhibitor, Cell Permeable | Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu | CAS No. 592517-80-1
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Description: Cell permeable NFAT inhibitor
Alternative Names: 11R-VIVIT
Product Details
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Biological Activity

NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.

Technical Data

M.Wt:
3573.15
Formula:
C147H259N67O36S
Sequence:
RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
592517-80-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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