NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ
-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2
mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Cell permeable.
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All Tocris products are intended for laboratory research use only.
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.
Elloumi et al.
PLoS One, 2012;7:e34172