Catalog Number: 5710
Alternate Names: 11R-VIVIT
Biological Activity
NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.
Technical Data
  • M.Wt:
    3573.15
  • Formula:
    C147H259N67O36S
  • Sequence:
    RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    592517-80-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.
    Elloumi et al.
    PLoS One, 2012;7:e34172
  2. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice.
    Noguchi et al.
    Nat.Med., 2004;10:305

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