NGFRAP1/BEX3/NADE Antibody Blocking Peptide

Name: NGFRAP1/BEX3/NADE Antibody Blocking Peptide
Brand: Novus Biologicals
SKU: NBP1-77149PEP
Price: 169 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-77149PEP

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Source

Synthetic

Applications

Antibody Competition

View all NGFRAP1/BEX3 Proteins and Enzymes »

Product Specifications

Description

A blocking peptide containing 14 amino acids near the carboxy terminus of human NADE.

Source: Synthetic

(Accession #: NP_996798)

Application Notes

This peptide is useful as a blocking peptide for NBP1-77149.

For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Scientific Data Images for NGFRAP1/BEX3/NADE Antibody Blocking Peptide

Western Blot: NGFRAP1/BEX3/NADE Antibody Blocking Peptide [NBP1-77149PEP]

Western Blot: NADE Peptide [NBP1-77149PEP] - blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C

Western Blot: NGFRAP1/BEX3/NADE Antibody - BSA Free [NBP1-77149] -

Western Blot: NGFRAP1/BEX3/NADE Antibody - BSA Free [NBP1-77149] - Western blot analysis of NGFRAP1/BEX3/NADE in Human brain cell lysates with NGFRAP1/BEX3/NADE antibody at 1 u/mL in the presence (A) or absence (B) of blocking peptide.

Formulation, Preparation, and Storage

NBP1-77149PEP

Formulation	PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
Preservative	0.02% Sodium Azide
Concentration	0.2 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20C. Avoid freeze-thaw cycles.

Background: NGFRAP1/BEX3

The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Coexpression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

Long Name

Nerve Growth Factor Receptor Associated Protein 1

Alternate Names

BEX3, HGR74, NADE

Gene Symbol

BEX3

Additional NGFRAP1/BEX3 Products

Product Documents for NGFRAP1/BEX3/NADE Antibody Blocking Peptide

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Product Specific Notices for NGFRAP1/BEX3/NADE Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

Related Research Areas

Apoptosis Adaptor Proteins

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