NICE 01

Tocris Bioscience | Catalog # 8088

Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
Tocris Bioscience

Key Product Details

Description

Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
View all Protein Dimerizers »

Product Description

NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.

Product Specifications for NICE 01

Molecular Weight

1206.85

Formula

C63H76ClN7O13S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

CAS Number

2982819-94-1

PubChem ID

169183208

InChI Key

USCBOLCYUGPYAF-YUZLDYPQSA-N

SMILES

O=C(O[C@H](CCC1=CC=C(C(OC)=C1)OC)C2=CC=CC(OCC(NCCOCCOCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)=O)=C2)[C@H]7N(CCCC7)C([C@@H](CC)C8=CC(OC)=C(C(OC)=C8)OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 60.34 50

Preparing Stock Solutions for NICE 01

The following data is based on the product molecular weight 1206.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.66 mL 8.29 mL 16.57 mL
2.5 mM 0.33 mL 1.66 mL 3.31 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
25 mM 0.03 mL 0.17 mL 0.33 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NICE 01

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NICE 01

For research use only

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