Niflumic acid (CAS 4394-00-7): R&D Systems
Catalog Number: 4112
Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicotinic acid
Biological Activity
Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
Technical Data
  • M.Wt:
    282.22
  • Formula:
    C13H9F3N2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at RT
  • CAS No:
    4394-00-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview.
    Famaey
    Inflamm.Res., 1997;46:437
  2. Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids.
    Ottolia and Toro
    Biophys.J., 1994;67:2272
  3. Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
    Hu et al.
    Pflugers Arch., 2010;459:579
  4. Multiple tyrosine metabolites are GPR35 agonists.
    Deng et al.
    Sci.Rep., 2012;2:373
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Niflumic acid include:

1 Citations: Showing 1 - 1

  1. SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
    Authors: Cao Et al.
    J Neuroinflammation 2014;289:23189

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