Niflumic acid

Tocris Bioscience | Catalog # 4112

Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist
Tocris Bioscience
Discontinued Product
4112 has been discontinued. View all Cyclooxygenase Inhibitors products.

Key Product Details

Description

Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist
View all Cyclooxygenase Inhibitors »

Product Description

Niflumic acid is a nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

Product Specifications for Niflumic acid

Molecular Weight

282.22

Formula

C13H9F3N2O2

Storage

Store at RT

Chemical Name

2-[3-(Trifluoromethyl)anilino]nicotinic acid

CAS Number

4394-00-7

PubChem ID

4488

InChI Key

JZFPYUNJRRFVQU-UHFFFAOYSA-N

SMILES

O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.22 100
Ethanol 28.22 100

Preparing Stock Solutions for Niflumic acid

The following data is based on the product molecular weight 282.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.72 mL 35.43 mL
5 mM 0.71 mL 3.54 mL 7.09 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for Niflumic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Niflumic acid

For research use only

Customer Reviews for Niflumic acid (1)

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  • Niflumic acid increases non-selective cationic current in cardiomyocytes
    Name: Chintan Koyani
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 10/23/2018
    Non-selective cationic current was measured in guinea pig cardiomyocytes before and after superfusion with 100 µM niflumic acid for 10 min. Compared to time matched rundown, niflumic acid significantly increased inward as well as outward non-selective cationic current in cardiomyocytes.
    Niflumic acid 4112

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