Niflumic acid
Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicotinic acid
Biological Activity
Niflumic acid is a nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview.
Famaey
Inflamm.Res., 1997;46:437 -
Multiple tyrosine metabolites are GPR35 agonists.
Deng et al.
Sci.Rep., 2012;2:373 -
Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids.
Ottolia and Toro
Biophys.J., 1994;67:2272 -
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Hu et al.
Pflugers Arch., 2010;459:579
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Citations for Niflumic acid
The citations listed below are publications that use Tocris products. Selected citations for Niflumic acid include:
2 Citations: Showing 1 - 2
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Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.
Authors: Amjad Et al.
J Gen Physiol 2015;145:285
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SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
Authors: Cao Et al.
J Neuroinflammation 2014;289:23189
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