Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicotinic acid
Biological ActivityNiflumic acid is a nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
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In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview.
Multiple tyrosine metabolites are GPR35 agonists.
Deng et al.
Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids.
Ottolia and Toro
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Hu et al.
Pflugers Arch., 2010;459:579
Citations for Niflumic acid
The citations listed below are publications that use Tocris products. Selected citations for Niflumic acid include:
2 Citations: Showing 1 - 2
Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.
Authors: Amjad Et al.
J Gen Physiol 2015;145:285
SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
Authors: Cao Et al.
J Neuroinflammation 2014;289:23189
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Non-selective cationic current was measured in guinea pig cardiomyocytes before and after superfusion with 100 µM niflumic acid for 10 min. Compared to time matched rundown, niflumic acid significantly increased inward as well as outward non-selective cationic current in cardiomyocytes.