Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
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In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview.
Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids.
Ottolia and Toro
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Hu et al.
Pflugers Arch., 2010;459:579
Multiple tyrosine metabolites are GPR35 agonists.
Deng et al.
The citations listed below are publications that use Tocris products. Selected citations for Niflumic acid include:
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