Nintedanib

Catalog # Availability Size / Price Qty
7049/10
7049/50
Nintedanib | CAS No. 656247-17-5 | VEGF Receptor Inhibitors
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Description: Potent VEGFR, PDGFR and FGFR inhibitor

Chemical Name: Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate

Purity: ≥98%

Product Details
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Biological Activity

Potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

Technical Data

M.Wt:
539.64
Formula:
C31H33N5O4
Solubility:
Soluble to 2 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
656247-17-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
    Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ
    Cancer Res., 2008;68(12):4774-82.

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