Nintedanib

Key Product Details

Product Description

Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC₅₀ values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC₅₀ values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

Product Specifications for Nintedanib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Nintedanib

The following data is based on the product molecular weight 539.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	92.65 mL	463.27 mL	926.54 mL
0.1 mM	18.53 mL	92.65 mL	185.31 mL
0.2 mM	9.27 mL	46.33 mL	92.65 mL
1 mM	1.85 mL	9.27 mL	18.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Hilberg BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008 PMID: 18559524

Product Documents for Nintedanib