Catalog Number: 5293
Chemical Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Biological Activity
Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.
Technical Data
  • M.Wt:
    285.26
  • Formula:
    C13H11N5O3
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1414963-82-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model.
    Shimozono et al.
    Mol.Pharmacol., 2013;84:62

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