Inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50
values are 8.3 μ
M, 132 μ
M and 1.7 mM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms.
Onda et al.
Capturing adenylyl cyclases as potential drug targets.
Pierre et al.
Nat.Rev.Drug Discov., 2009;8:321