Chemical Name: 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Biological ActivityNKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms.
Onda et al.
Capturing adenylyl cyclases as potential drug targets.
Pierre et al.
Nat.Rev.Drug Discov., 2009;8:321
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