Biological ActivityNLS-StAx-h is a Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
(Modifications: Val-7 = Val-PEG2, Arg-8 = Arg-9 = Arg-12 = Arg-20 = Arg-21 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-24 = homo-Arg & C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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