Biological ActivityWnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
(Modifications: Val-7 = Val-PEG2, Arg-8 = homo-Arg, Arg-9 = homo-Arg, Arg-12 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-20 = homo-Arg, Arg-21 = homo-Arg, Arg-24 = homo-Arg;
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Cell permeable stapled peptide inhibitor of Wnt signaling that targets �-catenin protein-protein Interactions.
Dietrich et al.
Cell Chem.Biol., 2017;24:958
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
Reviews for NLS-StAx-h
There are currently no reviews for this product. Be the first to review NLS-StAx-h and earn rewards!
Have you used NLS-StAx-h?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image