NNC 05-2090 hydrochloride
Chemical Name: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Purity: ≥98%
Biological Activity
NNC 05-2090 hydrochloride is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
Thomsen et al.
Br.J.Pharmacol., 1997;120:983 -
Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1.
Dalby et al.
Epilepsy Res., 1997;28:51
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Citation for NNC 05-2090 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NNC 05-2090 hydrochloride include:
1 Citation: Showing 1 - 1
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Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.
Authors: Wang Et al.
Sleep 2015;9:188
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