NNC 05-2090 hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:2747
Chemical Name:1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).
Technical Data
  • M.Wt:
    451.01
  • Formula:
    C27H30N2O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 13 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    184845-18-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NNC 05-2090 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.
    Authors: Wang Et al.
    Sleep  2015;9:188

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