NNC 05-2090 hydrochloride

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NNC 05-2090 hydrochloride | CAS No. 184845-18-9 | GABA Transporter Inhibitors
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Description: GABA uptake inhibitor; moderately BGT-1 selective

Chemical Name: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).

Technical Data

M.Wt:
451.01
Formula:
C27H30N2O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 13 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
184845-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for NNC 05-2090 hydrochloride

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