NNC 05-2090 hydrochloride
Chemical Name: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Biological ActivityNNC 05-2090 hydrochloride is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
Thomsen et al.
Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1.
Dalby et al.
Epilepsy Res., 1997;28:51
Citation for NNC 05-2090 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NNC 05-2090 hydrochloride include:
1 Citation: Showing 1 - 1
Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.
Authors: Wang Et al.
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