NNC 55-0396 dihydrochloride
Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
Biological ActivityNNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
Chen et al.
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha
Huang et al.
Citations for NNC 55-0396 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:
9 Citations: Showing 1 - 9
TRPV4 is the temperature-sensitive ion channel of human sperm.
Authors: Mundt Et al.
Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
Authors: Senadheera Et al.
Proc Natl Acad Sci U S A 2013;305:R917
Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei.
Authors: Schneider Et al.
J Neurophysiol 2013;109:2282
The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
Authors: Tzeng Et al.
Cardiovasc Res 2012;96:533
Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
Authors: Baillie Et al.
Am J Physiol Regul Integr Comp Physiol 2012;63:362
Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling.
Authors: Goswami Et al.
J Neurosci 2012;32:14294
The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
Authors: Abe Et al.
PLoS One 2011;108:12497
Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.
Authors: Kuo Et al.
J Cereb Blood Flow Metab 2010;30:1226
Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
Authors: Chen Et al.
J Neurosci 2010;30:10360
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