NNC 55-0396 dihydrochloride

Key Product Details

Product Description

NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC₅₀ values of 6.8 and > 100 μM for inhibition of Ca_v3.1 T-type channels and HVA currents respectively in INS-1 cells.

Product Specifications for NNC 55-0396 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NNC 55-0396 dihydrochloride

The following data is based on the product molecular weight 564.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.09 mL	35.43 mL	70.85 mL
1.25 mM	1.42 mL	7.09 mL	14.17 mL
2.5 mM	0.71 mL	3.54 mL	7.09 mL
12.5 mM	0.14 mL	0.71 mL	1.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

• Chen Ca_V3.2 T-type Ca²⁺ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 2010 PMID: 20685979
• Huang NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 2004 PMID: 14718587

Product Documents for NNC 55-0396 dihydrochloride