NNC 55-0396 dihydrochloride

  ( 8 citations )    
Product Datasheet
Catalog Number:2268
Chemical Name:(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
Product Details
Citations (8)
Reviews
Biological Activity
Highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
Technical Data
  • M.Wt:
    564.57
  • Formula:
    C30H38FN3O2.2HCl
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    357400-13-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:

8 Citations: Showing 1 - 8
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  1. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
    Authors: Senadheera Et al.
    Proc Natl Acad Sci U S A  2013;305:R917
  2. Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei.
    Authors: Schneider Et al.
    J Neurophysiol  2013;109:2282
  3. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
    Authors: Tzeng Et al.
    Cardiovasc Res  2012;96:533
  4. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
    Authors: Baillie Et al.
    Am J Physiol Regul Integr Comp Physiol  2012;63:362
  5. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling.
    Authors: Goswami Et al.
    J Neurosci  2012;32:14294
  6. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    PLoS One  2011;108:12497
  7. Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.
    Authors: Kuo Et al.
    J Cereb Blood Flow Metab  2010;30:1226
  8. Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
    Authors: Chen Et al.
    J Neurosci  2010;30:10360

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