NNC 55-0396 dihydrochloride

Catalog # Availability Size / Price Qty
NNC 55-0396 dihydrochloride | CAS No. 357400-13-6 | Cav3.x Channel Blockers
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Description: Highly selective CaV3.x blocker

Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride

Purity: ≥98%

Product Details
Citations (9)

Biological Activity

NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

Technical Data

Soluble to 25 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NNC 55-0396 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:

9 Citations: Showing 1 - 9

  1. TRPV4 is the temperature-sensitive ion channel of human sperm.
    Authors: Mundt Et al.
    Elife  2018;7
  2. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
    Authors: Senadheera Et al.
    Proc Natl Acad Sci U S A  2013;305:R917
  3. Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei.
    Authors: Schneider Et al.
    J Neurophysiol  2013;109:2282
  4. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
    Authors: Tzeng Et al.
    Cardiovasc Res  2012;96:533
  5. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
    Authors: Baillie Et al.
    Am J Physiol Regul Integr Comp Physiol  2012;63:362
  6. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling.
    Authors: Goswami Et al.
    J Neurosci  2012;32:14294
  7. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    PLoS One  2011;108:12497
  8. Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.
    Authors: Kuo Et al.
    J Cereb Blood Flow Metab  2010;30:1226
  9. Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
    Authors: Chen Et al.
    J Neurosci  2010;30:10360


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