Catalog Number: 2268
Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
Biological Activity
Highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
Technical Data
  • M.Wt:
    564.57
  • Formula:
    C30H38FN3O2.2HCl
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    357400-13-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha
    Huang et al.
    J.Pharmacol.Exp.Ther., 2004;309:193
  2. CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
    Chen et al.
    J.Neurosci., 2010;30:10360
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:

5 Citations: Showing 1 - 5
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  1. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
    Authors: Senadheera Et al.
    Proc Natl Acad Sci U S A 2013;305:R917
  2. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
    Authors: Tzeng Et al.
    Cardiovasc Res 2012;96:533
  3. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
    Authors: Baillie Et al.
    Am J Physiol Regul Integr Comp Physiol 2012;63:362
  4. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    PLoS One 2011;108:12497
  5. Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.
    Authors: Kuo Et al.
    J Cereb Blood Flow Metab 2010;30:1226

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