NNC 55-0396 dihydrochloride
Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
Biological ActivityHighly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha
Huang et al.
CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
Chen et al.
Citations for NNC 55-0396 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:
9 Citations: Showing 1 - 9
TRPV4 is the temperature-sensitive ion channel of human sperm.
Authors: Mundt Et al.
Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
Authors: Senadheera Et al.
Proc Natl Acad Sci U S A 2013;305:R917
Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei.
Authors: Schneider Et al.
J Neurophysiol 2013;109:2282
The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
Authors: Tzeng Et al.
Cardiovasc Res 2012;96:533
Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
Authors: Baillie Et al.
Am J Physiol Regul Integr Comp Physiol 2012;63:362
Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling.
Authors: Goswami Et al.
J Neurosci 2012;32:14294
The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
Authors: Abe Et al.
PLoS One 2011;108:12497
Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.
Authors: Kuo Et al.
J Cereb Blood Flow Metab 2010;30:1226
Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
Authors: Chen Et al.
J Neurosci 2010;30:10360
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