Potent non-peptide agonist for the NOP receptor (EC50
= 305 nM, Ki
= 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo
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(8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist.
Thomsen and Hohlweg
The citations listed below are publications that use Tocris products. Selected citations for NNC 63-0532 include:
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