Catalog Number: 1780
Chemical Name: 8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Biological Activity
Potent non-peptide agonist for the NOP receptor (EC50 = 305 nM, Ki = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    443.54
  • Formula:
    C27H29N3O3
  • Solubility:
    Soluble to 5 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    250685-44-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist.
    Thomsen and Hohlweg
    Br.J.Pharmacol., 2000;131:903
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NNC 63-0532 include:

1 Citations: Showing 1 - 1

  1. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
    Authors: Gear Et al.
    Neuroscience 2014;257:139

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