Catalog # Availability Size / Price Qty
Nocodazole | CAS No. 31430-18-9 | Microtubule Binding Compounds
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Description: Microtubule inhibitor

Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester

Purity: ≥95%

Product Details
Citations (12)

Biological Activity

Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

Technical Data

Soluble to 50 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Nocodazole

The citations listed below are publications that use Tocris products. Selected citations for Nocodazole include:

12 Citations: Showing 1 - 10

  1. Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.
    Authors: Bernier Et al.
    Cell Rep  2019;27:2895
  2. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
    Authors: Paonessa Et al.
    Cell Rep  2019;26:582
  3. Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells.
    Authors: Romero Et al.
    Nat Commun  2018;9:4010
  4. Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress.
    Authors: Macheret and Halazonetis
    Nature  2018;555:112
  5. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.
    Authors: Guo Et al.
    Front Cell Neurosci  2016;18:202
  6. Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.
    Authors: Lin Et al.
    Nat Commun  2015;6:18577
  7. Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells.
    Authors: Tauchman Et al.
    Nat Cell Biol  2015;6:10036
  8. Capture of microtubule plus-ends at the actin cortex promotes axophilic neuronal migration by enhancing microtubule tension in the leading process.
    Authors: Hutchins and Wray
    Methods Mol Biol  2014;8:400
  9. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
    Authors: Melemedjian Et al.
    Mol Pain  2014;10:45
  10. LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.
    Authors: Seese Et al.
    J Neurosci  2012;32:7403


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