Nocodazole

Tocris Bioscience | Catalog # 1228

Microtubule inhibitor
Tocris Bioscience

Key Product Details

Description

Microtubule inhibitor
View all Microtubule Binding Compounds »

Product Description

Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

Product Specifications for Nocodazole

Molecular Weight

301.32

Formula

C14H11N3O3S

Storage

Store at RT

Purity

≥95% (HPLC)

Chemical Name

[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester

CAS Number

31430-18-9

PubChem ID

4122

InChI Key

KYRVNWMVYQXFEU-UHFFFAOYSA-N

SMILES

COC(=O)NC1=NC2=CC(=CC=C2N1)C(=O)C1=CC=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.07 50

Preparing Stock Solutions for Nocodazole

The following data is based on the product molecular weight 301.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.64 mL 33.19 mL 66.37 mL
2.5 mM 1.33 mL 6.64 mL 13.27 mL
5 mM 0.66 mL 3.32 mL 6.64 mL
25 mM 0.13 mL 0.66 mL 1.33 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 148 publications citing the usage of this product.

Product Documents for Nocodazole

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Nocodazole

For research use only

Related Research Areas

Microtubules

Customer Reviews for Nocodazole (1)

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  • Microtubule disruption
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Brain slice
    Verified Customer | Posted 01/30/2018
    Used in brain slcies to disturb microtubule dynamics. Effect on cell shape was observed within minutes

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