Nocodazole

Catalog # Availability Size / Price Qty
1228/10
Nocodazole | CAS No. 31430-18-9 | Microtubule Binding Compounds
1 Image
Description: Microtubule inhibitor

Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester

Purity: ≥95%

Product Details
Citations (12)
Reviews

Biological Activity

Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

Technical Data

M.Wt:
301.32
Formula:
C14H11N3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥95%
Storage:
Store at RT
CAS No:
31430-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Nocodazole

The citations listed below are publications that use Tocris products. Selected citations for Nocodazole include:

12 Citations: Showing 1 - 10

  1. Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.
    Authors: Bernier Et al.
    Cell Rep  2019;27:2895
  2. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
    Authors: Paonessa Et al.
    Cell Rep  2019;26:582
  3. Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells.
    Authors: Romero Et al.
    Nat Commun  2018;9:4010
  4. Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress.
    Authors: Macheret and Halazonetis
    Nature  2018;555:112
  5. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.
    Authors: Guo Et al.
    Front Cell Neurosci  2016;18:202
  6. Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.
    Authors: Lin Et al.
    Nat Commun  2015;6:18577
  7. Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells.
    Authors: Tauchman Et al.
    Nat Cell Biol  2015;6:10036
  8. Capture of microtubule plus-ends at the actin cortex promotes axophilic neuronal migration by enhancing microtubule tension in the leading process.
    Authors: Hutchins and Wray
    Methods Mol Biol  2014;8:400
  9. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
    Authors: Melemedjian Et al.
    Mol Pain  2014;10:45
  10. LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.
    Authors: Seese Et al.
    J Neurosci  2012;32:7403

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Nocodazole

There are currently no reviews for this product. Be the first to review Nocodazole and earn rewards!

Have you used Nocodazole?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.