Catalog Number: 1228
Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester
Biological Activity
Microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.
Technical Data
  • M.Wt:
    301.32
  • Formula:
    C14H11N3O3S
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at RT
  • CAS No:
    31430-18-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.
    Vasquez et al.
    Mol.Biol.Cell, 1997;8:973
  2. Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.
    Webb et al.
    Int.J.Biochem.Cell Biol., 2004;36:2541
  3. Methods in mammalian autophagy research.
    Mizushima et al.
    Cell, 2010;140:313
  4. Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery.
    Lin et al.
    Elife, 2014;3:e04766

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