Nogo-66 (1-40)

   
Product Datasheet
Catalog Number:1984
Alternate Names:NEP1-40, Nogo Extracellular Peptide, 1-40
Chemical Name:
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Biological Activity
Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo.
Technical Data
  • M.Wt:
    4625.16
  • Formula:
    C206H324N56O65
  • Sequence:
    RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS

    (Modifications: Arg-1 = N-terminal Ac, Ser-40 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    475221-20-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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