Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro
. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo
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Nogo-66 receptor antagonist peptide promotes axonal regeneration.
GrandPre et al.
Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.
Liu et al.
Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury.
Li and Strittmatter