Biological ActivityNogo-66 (1-40) is a peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo.
(Modifications: Arg-1 = N-terminal Ac, Ser-40 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Nogo-66 receptor antagonist peptide promotes axonal regeneration.
GrandPre et al.
Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.
Liu et al.
Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury.
Li and Strittmatter
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