Noscapine hydrochloride

Key Product Details

Product Description

Noscapine hydrochloride is an opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA₂ = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF-κB signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.

Product Specifications for Noscapine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Noscapine hydrochloride

The following data is based on the product molecular weight 449.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.45 mL	22.23 mL	44.46 mL
2.5 mM	0.89 mL	4.45 mL	8.89 mL
5 mM	0.44 mL	2.22 mL	4.45 mL
25 mM	0.09 mL	0.44 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Sung Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-κB signaling pathway. Cancer Res. 2010 PMID: 20354190
• Mahmoudian and Mojaverian Effect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced smooth muscle contraction in the isolated ileum of the guinea-pig. Acta Physiol.Hung. 2001 PMID: 12162581
• Mourey [³H]Noscapine binding sites in brain: relationship to indoleamines and the phosphoinositide and adenylyl cyclase messenger systems. Mol.Pharmacol. 1992 PMID: 1331753
• Landen Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. Cancer Res. 2002 PMID: 12124349

Product Documents for Noscapine hydrochloride