Noscapine hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:1697
Chemical Name:(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone hydrochloride
Product Details
Citations (1)
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Biological Activity
Opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF-κB signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.
Technical Data
  • M.Wt:
    449.88
  • Formula:
    C22H23NO7.HCl
  • Solubility:
    Soluble to 50 mM in 1eq. HCl
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    912-60-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Noscapine hydrochloride include:

1 Citations: Showing 1 - 1

  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552

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