NoxA1ds

Tocris Bioscience | Catalog # 5848

Potent and selective NADPH oxidase 1 (NOX1) inhibitor
Tocris Bioscience
Discontinued Product
5848 has been discontinued. View all NADPH Oxidase Inhibitors products.

Key Product Details

Description

Potent and selective NADPH oxidase 1 (NOX1) inhibitor
View all NADPH Oxidase Inhibitors »

Product Description

NoxA1ds is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.

Product Specifications for NoxA1ds

Molecular Weight

1125.33

Formula

C50H88N14O15

Storage

Store at -20°C

CAS Number

1435893-78-9

PubChem ID

121513898

InChI Key

DHBOJLLJKHKZGT-XTGVMIFDSA-N

SMILES

[H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for NoxA1ds

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NoxA1ds

For research use only

Related Research Areas

Oxidases and Oxygenases
Redox Enzymes

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