NP3-253

Key Product Details

Product Description

NP3-253 is a potent and selective NLRP3 inflammasome inhibitor (IL-1β IC₅₀ = 0.7 nM and 8 nM in THP1-1 cells and whole blood, respectively). It displays selectivity for NLRP3 over an off-target panel of 29 proteins, when tested up to 10 μM. In vitro, NP3-253 blocks IL-1β production and IL-18 maturation and pyroptosis. In mouse models, it blocks IL-1β secretion in the peritoneum, blood and cerebrospinal fluid. Brain penetrant and orally bioavailable.

Product Specifications for NP3-253

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NP3-253

The following data is based on the product molecular weight 380.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for NP3-253