NPEC-caged-dopamine

Catalog # Availability Size / Price Qty
3992/10
Non-selective Dopamine Receptor Agonists Small Molecule
1 Image
Description: Caged dopamine

Chemical Name: (N)-1-(2-Nitrophenyl)ethylcarboxy-3,4-dihydroxyphenethylamine

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of dopamine (Cat. No 3548); releases dopamine leading to D1 receptor activation upon UV light illumination (360 nm). Induces PKA activation and c-Fos expression in cortical and striatal neurons, with striatal neurons demonstrating a significantly greater detection and sensitivity to sub-second dopamine signals as compared to cortical neurons.

Technical Data

M.Wt:
346.33
Formula:
C17H18N2O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1257326-23-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Striatal neurones have a specific ability to respond to phasic DA release.
    Castro et al.
    J.Physiol., 2013;591:3197

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Citations for NPEC-caged-dopamine

The citations listed below are publications that use Tocris products. Selected citations for NPEC-caged-dopamine include:

2 Citations: Showing 1 - 2

  1. Detection of phasic DA by D1 and D2 striatal medium spiny neurons.
    Authors: Yapo Et al.
    J.Physiol.  2017;595:7451
  2. Striatal neurones have a specific ability to respond to phasic DA release.
    Authors: Castro Et al.
    J.Physiol.  2013;591:3197

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