Catalog Number: 3992
Chemical Name: (N)-1-(2-Nitrophenyl)ethylcarboxy-3,4-dihydroxyphenethylamine
Biological Activity
NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of dopamine (Cat. No 3548); releases dopamine leading to D1 receptor activation upon UV light illumination (360 nm). Induces PKA activation and c-Fos expression in cortical and striatal neurons, with striatal neurons demonstrating a significantly greater detection and sensitivity to sub-second dopamine signals as compared to cortical neurons.
Technical Data
  • M.Wt:
    346.33
  • Formula:
    C17H18N2O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    1257326-23-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Striatal neurones have a specific ability to respond to phasic dopamine release.
    Castro et al.
    J.Physiol. [Epub ahead of print], 2013;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NPEC-caged-dopamine include:

2 Citations: Showing 1 - 2
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  1. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons.
    Authors: Yapo Et al.
    J.Physiol. 2017;
  2. Striatal neurones have a specific ability to respond to phasic dopamine release.
    Authors: Castro Et al.
    J.Physiol. 2013;591:3197

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