-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+
concentrations elicited by human Ca2+
receptors expressed in HEK293 cells (IC50
= 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50
= 41 nM). Orally active calcilytic compound.
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All Tocris products are intended for laboratory research use only.
The search for calcium receptor antagonists (calcilytics).
Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis.
Huang and Breitwieser
Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.
Nemeth et al.
The citations listed below are publications that use Tocris products. Selected citations for NPS 2143 hydrochloride include:
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