NPS 2143 hydrochloride

Catalog # Availability Size / Price Qty
3626/10
3626/50
NPS 2143 hydrochloride | CAS No. 324523-20-8 | Calcium-Sensing Receptor Antagonists
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Description: Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent

Chemical Name: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride

Purity: ≥99%

Product Details
Citations (8)
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Biological Activity

Selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41 nM). Orally active calcilytic compound.

Technical Data

M.Wt:
445.38
Formula:
C24H25ClN2O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
324523-20-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NPS 2143 hydrochloride

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