NPS 2143 hydrochloride

  ( 6 citations )    
Product Datasheet
Catalog Number:3626
Chemical Name:2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41 nM). Orally active calcilytic compound.
Technical Data
  • M.Wt:
    445.38
  • Formula:
    C24H25ClN2O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    324523-20-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NPS 2143 hydrochloride include:

6 Citations: Showing 1 - 6
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  1. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Authors: Yarova Et al.
    Diabetologia  2015;7:284ra60
  2. Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension.
    Authors: Yamamura Et al.
    Sci Transl Med  2015;10:e0138384
  3. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation.
    Authors: Dai Et al.
    Cell Death Differ  2014;21:568
  4. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection.
    Authors: Kim Et al.
    Ann Clin Transl Neurol  2014;1:851
  5. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.
    Authors: Diakogiannaki Et al.
    Front Mol Neurosci  2013;56:2688
  6. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
    Authors: Yamamura Et al.
    Circ Res  2012;111:469

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