NQDI 1

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation
   RR Sama, C Fallini, R Gatto, JE McKeon, Y Song, MS Rotunno, S Penaranda, I Abdurakhma, JE Landers, G Morfini, ST Brady, DA Bosco
   Sci Rep, 2017;7(1):115.
2. Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.
   Song Y, Nagy M, Ni W, Tyagi N, Fenton W, Lopez-Giraldez F, Overton J, Horwich A, Brady S
   Proc Natl Acad Sci U S A, 2013;110(14):5428-33.
3. Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
   Bu et al.
   J.Med.Chem., 2001;44:2004
4. Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1).
   Volynets et al.
   J.Med.Chem., 2011;54:2680

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