Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester
Biological ActivityNQDI 1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
Bu et al.
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1).
Volynets et al.
Citation for NQDI 1
The citations listed below are publications that use Tocris products. Selected citations for NQDI 1 include:
1 Citation: Showing 1 - 1
ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition.
Authors: Song and Lee
Psychopharmacology (Berl) 2015;9:198
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