Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester
Biological ActivitySelective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
Bu et al.
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1).
Volynets et al.
Citation for NQDI 1
The citations listed below are publications that use Tocris products. Selected citations for NQDI 1 include:
1 Citation: Showing 1 - 1
ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition.
Authors: Song and Lee
Psychopharmacology (Berl) 2015;9:198
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