Catalog Number: 4429
Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester
Biological Activity
Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).
Technical Data
  • M.Wt:
    319.31
  • Formula:
    C19H13NO4
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    175026-96-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
    Bu et al.
    J.Med.Chem., 2001;44:2004
  2. Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1).
    Volynets et al.
    J.Med.Chem., 2011;54:2680
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NQDI 1 include:

1 Citations: Showing 1 - 1

  1. ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition.
    Authors: Song and Lee
    Psychopharmacology (Berl) 2015;9:198

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