Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
Biological ActivityHuman ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen et al.
Mechanism of action of a novel human ether-a-go-ao related gene channel activator.
Casis et al.
Activation of ERG2 potassium channel by the diphenylurea NS1643.
Elmedyb et al.
Citation for NS 1643
The citations listed below are publications that use Tocris products. Selected citations for NS 1643 include:
1 Citation: Showing 1 - 1
Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
Authors: Perissinotti Et al.
Biophys J 2015;108:1414
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NS 1643 was used to understand its potassium channel opening properties. The product performed well under experimental conditions. Dissolving in ethanol is a better option than disssolving in DMSO as opposed to other K.V channel openers.