NS 1643

Catalog # Availability Size / Price Qty
3062/10
3062/50
NS 1643 | CAS No. 448895-37-2 | Voltage-gated Potassium Channel Activators
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Description: KV11.1 (hERG) channel activator; antiarrhythmic

Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.

Technical Data

M.Wt:
380.24
Formula:
C15H10F6N2O3
Solubility:
Soluble to 100 mM in ethanol and to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
448895-37-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for NS 1643

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Standard K.v channel opener: Performed well in biological channel activation studies
By Sadequl Islam on 10/12/2018
Species: Mouse

NS 1643 was used to understand its potassium channel opening properties. The product performed well under experimental conditions. Dissolving in ethanol is a better option than disssolving in DMSO as opposed to other K.V channel openers.


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