Catalog Number: 3062
Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
Biological Activity
Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
    Hansen et al.
    Mol.Pharmacol., 2006;69:266
  2. Mechanism of action of a novel human ether-a-go-ao related gene channel activator.
    Casis et al.
    Mol.Pharmacol., 2006;69:658
  3. Activation of ERG2 potassium channel by the diphenylurea NS1643.
    Elmedyb et al.
    Neuropharmacology, 2007;53:283
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