Human ether-a-go-go related gene (hERG) KV
11.1 channel activator (EC50
= 10.5 μ
M). Exhibits different molecular mechanisms of action at KV
11.1 (hERG1) and KV
11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen et al.
Mechanism of action of a novel human ether-a-go-ao related gene channel activator.
Casis et al.
Activation of ERG2 potassium channel by the diphenylurea NS1643.
Elmedyb et al.