Catalog Number: 4462
Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Biological Activity
KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.
Technical Data
  • M.Wt:
    427.18
  • Formula:
    C15H10BrF3N6O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    343630-41-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].
    Hansen et al.
    Mol.Pharmacol., 2006;70:1319
  2. Restoring repolarization in LQT3.
    George
    Heart Rhythm., 2009;6:107
  3. Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
    Hansen et al.
    J.Pharmacol.Exp.Ther., 2007;321:996
  4. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials.
    Calloe et al.
    Biochem.Pharmacol., 2016;108:36

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