Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Biological ActivityKV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].
Hansen et al.
Restoring repolarization in LQT3.
Heart Rhythm., 2009;6:107
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
Hansen et al.
A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials.
Calloe et al.
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Product worked amazing on experimental conditions. Shows channel opening properties and must be dissolved in Tween 20–propylene glycol mixture.NS3623 affects the voltage-dependent potassium channel opening.