NS 3623

Tocris Bioscience | Catalog # 4462

KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
Tocris Bioscience

Key Product Details

Description

KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
View all Voltage-gated Potassium Channel Activators »

Product Description

NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.

Product Specifications for NS 3623

Molecular Weight

427.18

Formula

C15H10BrF3N6O

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea

CAS Number

343630-41-1

PubChem ID

9954236

InChI Key

JXPULDIATMTIIN-UHFFFAOYSA-N

SMILES

BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.72 100

Preparing Stock Solutions for NS 3623

The following data is based on the product molecular weight 427.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.70 mL 23.41 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Product Documents for NS 3623

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 3623

For research use only

Customer Reviews for NS 3623 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used NS 3623?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Product performs well as a channel opener in experimental conditions
    Name: Sadequl Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/12/2018
    Product worked amazing on experimental conditions. Shows channel opening properties and must be dissolved in Tween 20–propylene glycol mixture. NS3623 affects the voltage-dependent potassium channel opening.
    NS 3623 4462

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All