Catalog Number: 4462
Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Biological Activity
Human ether-a-go-go (hERG) KV11.1 potassium channel activator. Activates the IKr current and displays antiarrhythmic activity. Exhibits potential dual mode of action at the hERG inhibitory site; may also act as a partial blocker of KV11.1 (hERG) channels. Displays selectivity over the key cardiac potassium ion channels, KV7.1 (KCNQ1), KV1.5, and KV4.3. Suitable for both in vitro and in vivo use.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].
    Hansen et al.
    Mol.Pharmacol., 2006;70:1319
  2. Restoring repolarization in LQT3.
    Heart Rhythm., 2009;6:107
  3. Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
    Hansen et al.
    J.Pharmacol.Exp.Ther., 2007;321:996
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