Catalog Number: 4902
Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide
Biological Activity
Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.
Technical Data
  • M.Wt:
    260.16
  • Formula:
    C12H15Cl2NO
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    7497-07-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth.
    Remacle AG, Golubkov VS, Shiryaev SA, Dahl R, Stebbins JL, Chernov AV, Cheltsov AV, Pellecchia M, Strongin AY.
    Cancer Res;72(9):2339-49.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NSC 405020 include:

1 Citations: Showing 1 - 1

  1. Regulated delivery of molecular cargo to invasive tumour-derived microvesicles.
    Authors: Clancy Et al.
    Proc Natl Acad Sci U S A 2015;6:6919

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