Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide
Biological ActivityNSC 405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth.
Remacle AG, Golubkov VS, Shiryaev SA, Dahl R, Stebbins JL, Chernov AV, Cheltsov AV, Pellecchia M, Strongin AY.
Citations for NSC 405020
The citations listed below are publications that use Tocris products. Selected citations for NSC 405020 include:
2 Citations: Showing 1 - 2
MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness.
Authors: Kumar Et al.
Biophys J 2018;114:650
Regulated delivery of molecular cargo to invasive tumour-derived microvesicles.
Authors: Clancy Et al.
Proc Natl Acad Sci U S A 2015;6:6919
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