Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50
> 100 μ
mol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo
. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.
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All Tocris products are intended for laboratory research use only.
Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth.
Remacle AG, Golubkov VS, Shiryaev SA, Dahl R, Stebbins JL, Chernov AV, Cheltsov AV, Pellecchia M, Strongin AY.
The citations listed below are publications that use Tocris products. Selected citations for NSC 405020 include:
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