NSC 632839 hydrochloride
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Biological ActivityNSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
Aleo et al.
Cancer Res., 2006;66:9235
Citations for NSC 632839 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:
2 Citations: Showing 1 - 2
The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
Authors: Ryals Et al.
Front Cell Neurosci 2018;12:445
CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
Authors: Zeng Et al.
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Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound