Catalog Number: 2647
Alternate Names: F6
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Biological Activity
Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).
Technical Data
  • M.Wt:
    339.86
  • Formula:
    C21H21NO.HCl
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    157654-67-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
    Aleo et al.
    Cancer Res., 2006;66:9235
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:

1 Citations: Showing 1 - 1

  1. CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
    Authors: Zeng Et al.
    Nature 2016;7:11364

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