Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50
values are 15.65 and 16.23 μ
M in E1A and E1A/C9CN cells respectively).
Soluble to 25 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
Aleo et al.
Cancer Res., 2006;66:9235
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