NSC 663284

Key Product Details

Product Description

NSC 663284 is a potent, selective inhibitor of Cdc25 dual specificity phosphatases (K_i values are 29, 95 and 89 nM for human Cdc25A, Cdc25B₂ and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G₁ and G₂/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC₅₀ = 0.2 - 35 μM).

Product Specifications for NSC 663284

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NSC 663284

The following data is based on the product molecular weight 321.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.22 mL	31.08 mL	62.16 mL
2.5 mM	1.24 mL	6.22 mL	12.43 mL
5 mM	0.62 mL	3.11 mL	6.22 mL
25 mM	0.12 mL	0.62 mL	1.24 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Lazo Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J.Med.Chem. 2001 PMID: 11708908
• Pu Dual G₁ and G₂ phase inhibition by a novel, selective Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino)-quinoline-5,8-dione. J.Biol.Chem. 2002 PMID: 12356752
• Brisson Redox regulation of cdc25B by cell-active Quinolinediones. Mol.Pharmacol. 2005 PMID: 16155209

Product Documents for NSC 663284