NSC 663284

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1867/10
NSC 663284 | CAS No. 383907-43-5 | Cdc25 Phosphatase Inhibitors
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Description: Potent, selective Cdc25 phosphatase inhibitor

Chemical Name: 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione

Purity: ≥99%

Product Details
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Biological Activity

Potent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50 = 0.2 - 35 μM).

Technical Data

M.Wt:
321.76
Formula:
C15H16ClN3O3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
383907-43-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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