Potent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki
values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2
and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1
/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50
= 0.2 - 35 μ
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All Tocris products are intended for laboratory research use only.
Redox regulation of cdc25B by cell-active Quinolinediones.
Brisson et al.
Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
Lazo et al.
Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino)-quinoline-5,8-dione.
Pu et al.