Catalog Number: 5813
Chemical Name: N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester
Biological Activity
Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.
Technical Data
  • M.Wt:
    460.52
  • Formula:
    C21H36N2O9
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    144678-63-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a specific inhibitor of the dishevelled PDZ domain.
    Shan et al.
    Biochemistry, 2005;44:15495
  2. Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process.
    Wang et al.
    Exp.Cell Res., 2015;331:115
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