Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β
-induced differentiation of fibroblasts in vitro
. Reduces severity of pulmonary fibrosis in a mouse model.
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All Tocris products are intended for laboratory research use only.
Identification of a specific inhibitor of the dishevelled PDZ domain.
Shan et al.
Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process.
Wang et al.
Exp.Cell Res., 2015;331:115