NSC 66811

Catalog # Availability Size / Price Qty
2936/10
2936/50
Cat.No. 2936 - NSC 66811 | C23H20N2O | CAS No. 6964-62-1
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Description: MDM2 antagonist. Disrupts MDM2-p53 interaction

Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol

Purity: ≥97%

Product Details
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Biological Activity

Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

Technical Data

M.Wt:
340.42
Formula:
C23H20N2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
6964-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.
    Lu et al.
    J.Med.Chem., 2006;49:3759
  2. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.
    Shangary and Shaomeng
    Ann.Rev.Pharmacol.Toxicol., 2009;49:223

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