Catalog Number: 2936
Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Biological Activity
Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
Technical Data
  • M.Wt:
    340.42
  • Formula:
    C23H20N2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    6964-62-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.
    Lu et al.
    J.Med.Chem., 2006;49:3759
  2. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.
    Shangary and Shaomeng
    Ann.Rev.Pharmacol.Toxicol., 2009;49:223

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