NSC 87877

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NSC 87877 | CAS No. 56990-57-9 | Protein Tyrosine Phosphatase Inhibitors
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Description: Potent inhibitor of shp2 and shp1 PTP

Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid

Purity: ≥98%

Product Details
Citations (8)

Biological Activity

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Technical Data

Soluble to 50 mM in water and to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NSC 87877

The citations listed below are publications that use Tocris products. Selected citations for NSC 87877 include:

8 Citations: Showing 1 - 8

  1. Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis.
    Authors: Zhang and Lu
    J Biol Chem  2017;292:15481
  2. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
    Authors: Kim Et al.
    Cell  2017;168:1053
  3. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
    Authors: Taylor Et al.
    Immunity  2016;44:274
  4. Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking.
    Authors: Zhang Et al.
    J Biol Chem  2016;291:18856
  5. Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase.
    Authors: Pinzon-Guzman Et al.
    Int J Cancer  2015;55:152
  6. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway.
    Authors: Quintanar-Audelo Et al.
    J Biol Chem  2011;286:23102
  7. Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells.
    Authors: Abeyweera Et al.
    J Cell Biol  2011;192:675
  8. Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells.
    Authors: Fragale Et al.
    J Immunol  2011;186:1951


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