Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
Biological ActivityNSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Chen et al.
Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2.
Zhao et al.
hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation.
Redonde et al.
Citations for NSC 87877
The citations listed below are publications that use Tocris products. Selected citations for NSC 87877 include:
8 Citations: Showing 1 - 8
Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis.
Authors: Zhang and Lu
J Biol Chem 2017;292:15481
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
Authors: Kim Et al.
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
Authors: Taylor Et al.
Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking.
Authors: Zhang Et al.
J Biol Chem 2016;291:18856
Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase.
Authors: Pinzon-Guzman Et al.
Int J Cancer 2015;55:152
Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway.
Authors: Quintanar-Audelo Et al.
J Biol Chem 2011;286:23102
Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells.
Authors: Abeyweera Et al.
J Cell Biol 2011;192:675
Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells.
Authors: Fragale Et al.
J Immunol 2011;186:1951
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for NSC 87877
There are currently no reviews for this product. Be the first to review NSC 87877 and earn rewards!
Have you used NSC 87877?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image