Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50
values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μ
M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
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All Tocris products are intended for laboratory research use only.
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Chen et al.
Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2.
Zhao et al.
hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation.
Redonde et al.
The citations listed below are publications that use Tocris products. Selected citations for NSC 87877 include:
Showing Results 1 - 4 of 4