Catalog Number: 2613
Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
Biological Activity
Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
    Chen et al.
    Mol.Pharmacol., 2006;70:562
  2. Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2.
    Zhao et al.
    Dev.Neurobiol., 2007;67:1789
  3. hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation.
    Redonde et al.
    J.Thromb.Haemost., 2007;5:2476
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